To avoid casualties and economic loss caused by vehicle yawing motion during the tire blowout, first, by changing several key parameters of the characteristics, this article uses CarSim software and MATLAB/Simulink to establish a vehicle model of tire blowout based on the UniTire model. This model is implemented to simulate tire blowout caused by the change of the vehicle motion state. Second, considering the driver error and radical-operated steering wheel after tire blowout leads to runaway car problems. This article takes the target trajectory and actual trajectory of error and error rate as the system input; an adaptive fuzzy proportional-integral-derivative controller is designed to determine the vehicle steering wheel angle during the tire blowout and replace the driver to control the direction of the vehicle. The results indicate that the designed controller is capable of ensuring the vehicle constancy and keeping the vehicle on the original track.

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Drug-target interactions (DTIs) prediction plays a vital role in drug discovery and design. Current studies typically use only standard drug similarity and target similarity, but the influence of known interactions has not been taken into account. In this paper, we propose an ensembled computational approach called multi-similarity fusion and sparse dual-graph regularized matrix factorization (MSDGRMF) for DTIs prediction. Specifically, different similarities are integrated to mine more useful information from the known interactions. The dual-graph regularized matrix factorization is used to predict the DTIs, in which the manifold learning is used for the low-dimensional representation of the drugs and targets data. In addition, not all the information of drug pairs and target pairs is useful. Thus, the useless information is discarded by sparse process. The proposed MSDGRMF is evaluated and compared on some benchmark datasets. Comparison results show that the MSDGRMF is better than some state-of-the-art approaches. More importantly, the proposed method can contribute to predicting potential DTIs.INDEX TERMS Drug-target interactions prediction, multi-similarity fusion, dual-graph regularized matrix factorization, manifold learning.

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