Bottom-up synthesized quasi-2D Co3O4 nanoflakes demonstrate a remarkable chemiresistive response towards chemically akin alcohol vapors in a mixture with air.

New N 4 -Hydroxycytidine Derivatives: Synthesis and Antiviral Activity. -Various derivatives of the antiviral N 4 -hydroxycytidine (Ia) are prepared [cf. (Ib,c) and (II)]. Investigations concerning their pharmacological activity reveal that the acyloxy derivatives of type (I) exhihit potent antiviral effects, whereas the 5'-phosphonates are more cytotoxic than the parent compound (Ia). -(IVANOV, M. A.; ANTONOVA, E. V.; MAKSIMOV, A. V.; PIGUSOVA, L. K.; BELANOV, E. F.; ALEKSANDROVA*, L. A.; Collect.

Two series of N4-hydroxycytidine derivatives were synthesized and evaluated as potential antipox virus agents. Acylation of N4-hydroxycytidine (1) with an excess of acyl chloride or imidazolide yielded the corresponding N4-(acyloxy) derivatives. 5'-Phosphonates of 1 were prepared by the reaction of cytidine 5'-phosphonates with aqueous hydroxylamine hydrochloride (pH 6.0). Nucleoside 1 and its N4-(acyloxy) derivatives inhibited replication of pox viruses in cell cultures, N4-(pivaloyloxy)- and N4-(benzoyloxy)cytidines being the most potent. The synthesized 5'-phosphonates were more cytotoxic than the parent nucleoside.

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