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Myocardial infarction (MI) remains the leading cause of death in patients with coronary heart disease (СHD) worldwide. Over the past twenty years, there has been a tendency to increase the prevalence of congenital disorders of connective tissue. The relevance of this problem is due not only to the growing occurrence of undifferentiated connective tissue dysplasia (UCTD) and a variety of complications but also to medical and social problems resulting from associated somatic diseases. Considering the high social significance of the problem of CHD on the background of UCTD, and because it affects mainly people of working age, this study aimed to investigate stigmas of dysplasia in women with Q-MI on the background of UCTD. The most common stigmas of dysembryogenesis in patients with UCTD were various anomalies of the hands and feet (100%), ophthalmic stigmas and microanomalies of the auricles (90% each), varicose veins of the lower extremities (33.3%) and easy formation of hematomas at insignificant damage (20%). Correlations were found in women with UCTD between the number of markers and the frequency of detection of the diagonal fold of the earlobe (r=+0.79; p<0.05), blue sclera (r=+0.77; p<0.05), radial-lacunar type of iris (r=+0.66; p<0.05), varicose veins of the lower extremities (r=+0.73; p<0.05) and easy formation of hematomas at insignificant damage (r=+0.51; p<0.05). Thus, the above markers of UCTD can be considered as prognostic criteria for the complicated course of CHD, which will allow further development of new approaches to the detection of such individuals and their differentiated therapy.

Bacteriophages against methicillin resistant Staphylococcus aureus strains. Poniatovskyi V.A., Bondarchuk O.L., Prystupiuk M.O., Smikodub O.O., Shyrobokov V.P.Staphylococcus aureus is one of the most common opportunistic pathogens that causes a variety of diseases, from minor skin infections to life-threatening sepsis, meningitis, pneumonia and a number of other diseases. Particular attention was paid to methicillin-resistant Staphylococcus aureus (MRSA) strains with multiple drug resistance. The purpose of this study is investigation of the sensitivity of clinical isolates of Staphylococcus aureus, including methicillin-resistant strains, to bacteriophage drugs and determination of possibility of using this agent for the treatment of staphylococcal infections. A number of classical and modern microbiological methods for the isolation and identification of Staphylococcus aureus: an indication of genes, responsible for antibiotic resistance (PCR analysis), determination of sensitivity to antibiotics (disc diffusion method) and bacteriophages (spot test, Gracia method, Appelman method) were used in the study. The susceptibility analysis of Staphylococcus aureus with presence and absence of mecA gene to the commercial bacteriophage product -"PYOFAG ® BACTERIOPHAGE POLYVALENT" was performed. The results of the study showed that the total number of susceptible strains of bacteria was 95±0,2%. The use of investigational Bacteriophage drug for the treatment of furunculosis caused by MRSA has shown positive results. After one week of using the bacteriophage as monotherapy, the patient experienced regression of the clinical symptoms. For the period of use no adverse effects have been detected. Thus, the phage drugs using can become an important tool in the control of antibiotic-resistant strains, which cause a variety of infections in humans. Реферат. Бактеріофаги проти метицилін-резистентних штамів Staphylococcus aureus. Понятовський В.А., Бондарчук О.Л., Приступюк М.О., Смікодуб О.О., Широбоков В.П. Staphylococcus aureus є одним із найпоширеніших опортуністичних патогенів, що здатні викликати різноманітні захворювання: від незначних шкірних інфекцій до небезпечного для життя сепсису, менінгіту, пневмонії та ряду інших захворювань. Особлива увага приділяється метицилін-резистентним штамам Staphylococcus aureus (MRSA) зі стійкістю до багатьох лікарських засобів. Метою цього дослідження є вивчення чутливості клінічних ізолятів золотистого стафілокока, у тому числі метицилін-резистентних штамів, до бактеріофагового препарату та встановлення можливості використання цього засобу для лікування стафілококових інфекцій. У роботі використано ряд класичних і сучасних мікробіологічних методів виділення та ідентифікації мікроорганізмів,