Background: Culture-compatible interventions are important for the success of mental health programs in different communities. The Thinking Healthy Program (THP) proposed by WHO is an evidence-based intervention for the treatment of prenatal depression that requires adaptation in any country or culture. Methods: The THP was translated in two copies by two translators of Iranian origin with academic education in English. A panel of experts was held to perform content and face validations. A systematic review was conducted, the strategies of the program were presented using nominal group technique, and a pre-test was performed. Finally, both the mothers and peers were asked for their opinions through open-ended questions. Results: Some terms were changed and some images were modified. Sexual health content and a training session about natural childbirth were added. Most of the mothers and peers considered the program acceptable and understandable and the images appropriate, and suggested expanding the program to all health care centers. Conclusion: The Persian version of the THP seems to have adequate validity to be used in Iran.