Background & Objectives: Pain in Sciatica can be incredibly painful and intolerable which seeks immediate medical attention. Various treatment modalities are widely used but have side effects too. One of them is Ghati Yantra Raktamokshana (Bloodletting with modified cupping). This systematic review provides an assessment on evidence of pain management of Gridhrasi (Sciatica) by Ghati Yantra Raktamokshana (Bloodletting with Modified Cupping). Methods: The databases of PubMed, Scopus, Cochrane Library, AYUSH portal, Shodhganga, Clinical trial registry of India, Google scholar were searched systematically (since inception to February 2021) for relevant articles about the effect of Ghati Yantra Raktamokshana in pain management of Gridhrasi. All randomized controlled trials as well as non-randomized controlled trials, before and after studies and single group clinical studies assessing the efficacy of Ghati Yantra Raktamokshana in pain management of Gridhrasi was included. Results: The original search yielded 774 articles of which only 6 articles (1-pilot study, 1-case study and 4-single arm studies) met the inclusion criteria and they showed the effectiveness of Ghati Yantra Raktamokshana in Pain management of Gridhrasi. Interpretation & Conclusions: Though review shows that the Ghati Yantra Raktamokshana is effective in Pain management of Gridhrasi but due to the methodological and clinical heterogeneity and risk of bias of the included trials requires more strong evidences in terms of RCT’s with larger sample size and for longer duration to definitely conclude its effectiveness.

Background: Almost a year to the pandemic situation gone, but still no approved scientific treatment only experimental cocktail for novel coronavirus disease. Ayurveda as a complementary medicine, claims the Ayurveda drug has strong immunity boosting and anti-inflammatory benefits against the coronavirus. To get a global recognition, AYUSH system encourages to carry a randomized controlled clinical trial to treat novel coronavirus disease. In this study, we aimed to summarize the effectiveness of Ayurveda interventions and which interventions are most effective in management of COVID19 positive patients. Methods: To ensure relative efficacy of Ayurveda interventions in management of COVID 19 positive patients, we will systematically search randomized controlled trials and quasi-randomised controlled trials in electronic databases. Also, we will search unpublish material from pre-print servers and grey literature. Two independent researchers will conduct the selection process based on inclusion and exclusion criteria according to PRISMA guidelines. Upon selection, we will carry out quality assessment with the help of GRADE and risk of bias assessment using Cochrane Collaboration’s Risk of Bias Assessment Tool. Using R-3.4.1 software to process and analyse data. Result: The results of this study will be published in a peer-reviewed journal. Discussion: The findings from this study will provide directions for further research and provide helpful evidence for clinicians to formulate best Ayurveda treatment strategy for management of COVID-19 positive patients. Systematic review registration: International Prospective Register for Systematic Reviews (PROSPERO) number CRD42021267410.