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Antimicrobial resistance is a major global public health challenge threatening the utility of antibiotics. Inappropriate antibiotic prescribing and sales, using outside of the health sectors, and genetic factors are mainly influencing the development of antimicrobial resistance (AMR). Antibiotics abuse in human, wildlife, and farming practices have an enormous health impact. Recently approved antibiotics are anticipated to help stem this crisis. To fight against antibiotic resistance crisis, development of collaboration among concerned stakeholders to establish policies, initiatives, and investments for new agents can be auspicious. New methods of antibacterial drug identification and strategies, neutralize virulence factors, are the substitute approaches to address the AMR threat. Some novel approaches have also been taken to develop alternatives to typical antibiotics for bacterial infection. Here, we tried to highlight some of the key reasons behind antibiotic resistance, management, and burden. Moreover, this paper also discusses recent developments in this area and a brief overview of future antibacterial agents. J MEDICINE JUL 2019; 20 (1) : 38-45

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Innovative work behavior shown by employee activities that generate ideas, promote ideas, and implement ideas is very useful for organizational sustainability. This research seeks to improve innovative work behavior by analyzing the contribution of self-efficacy and organizational climate to ionovative work behavior. The research was conducted on non-permanent instructors at PT PLN (Persero) Pusdiklat with samples 149. Hypothesis testing uses parametric statistical analysis and RCA (Root Cause Analysis) method. The findings of this research: (1) If self-efficacy increases, innovative work behavior will increase; (2) if the organizational climate increases, innovative work behavior will increase; (3) If self-efficacy and organizational climate increase together, innovative work behavior will increase. Based on the RCA  (Root Cause Analysis) method, several priority indicators were found to improve innovative work behavior, namely: forming an innovation team, assigning internships / benchmarks, budgeting for awards, K3L training, creating Knowledge Capturing books, recruiting K3L HR, and book review.

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