One important step to achieve a sustainable transportation system is to control the impact and evaluate the effect of various influencing factors toward three dimensions of sustainability. Within this context, diverse analytical approaches have been developed to assess the sustainability level of various transportation systems, however, sustainability evaluation based on fuzzy multiple criteria decision-making approaches are still limited. In current research activity, an integrated quantitative evaluation technique is proposed to narrow the identified gap. The developed decision-making approach is consisted of two main phases. Firstly, fuzzy analytic hierarchy process is utilized to weigh the sustainability dimensions resulting in the incorporation of the experts' knowledge along with the evaluation process. Then, a proposed fuzzy inference mechanism is proposed to provide an indication on the performance of an evaluated road transportation system. The developed approach is applied on a real-world case study. Finally, future works are presented together with some concluding remarks.