Background: Diabetes mellitus type II is the most common endocrine disorder all over the world, which is characterized by metabolic abnormal conditions and many long term illness. These complications can lead to social threatening problems due to loss of jobs. Objectives: This study aimed at measuring the effects of Type II diabetes mellitus on hand grip and Pinch power of adult females in the city of Hail-KSA Methods: A cross-sectional study was carried out in the outpatient clinics of the King Khalid Hospital. Forty Female patient represented the sample of the study. A JAMAR dynamometer and a pinch gauge were used to measure the participants' hand holding action and Pinch power. Results: Statistical analysis showed a significant decrease (P≤ 0,05) of the hand grip and pinch power strength among patient with long standing diabetes as compared to healthy matched group. Conclusion :The results of the current study concluded that the hand muscles strength represented in grip and pinch power which are important parameters of hand function is significantly affected by long standing type 2 diabetes mellitus.