Although the coronavirus disease 2019 (COVID-19) pandemic is still ongoing, the path towards a better future is finally becoming clear as a result of the initiation of COVID-19 vaccination. While pneumonia was initially emphasized as the only complication of COVID-19, it has become clear that fatal complications, such as a thromboembolism, are also likely to occur. In the era of recurring coronavirus infections, it is important to identify the causes and risk factors regarding exacerbations in patients who may develop severe COVID-19. This review describes how to prevent COVID-19 exacerbations in the context of cardiovascular disease, especially exacerbations related to the vascular endothelium.

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