Background: The aim is to evaluate ferritin levels in fever caused by dengue virus and their association with the severity of infection with dengue virus in children. Subjects and Methods: It is a Prospective that was done for 1 year in the department of pediatrics. 56 reported cases with a history of dengue fever for clinical evaluation by positive IgG and IgM antibodies and positive NS1 antigen and were included in the sample. All 16-year-old subjects with clinical dengue suspicion presenting in the department of emergency. Results: Out of total of 56 children with mean age of the children were 11.5 years and SD 3.5 years, and 59% were male who were majority. Mean hospital stay duration was 5 3 days. Most of the patients in study discharged in 5-7 days of admission in hospital. The mean serum ferritin levels among cases with DHF were raised than those with DF with significant p-values of< 0.05 on Day 5 and 6 of illness. During Days 5, 6, and 7 after the onset of fever, the results for sensitivity were 83, 86, and 92 per cent respectively. Conclusion: The incidence of hyperferritinaemia in patients infected with dengue virus is suggestive of highly active use of ferritin level in serum is 1,200 ng/ml as a method for predicting progression to DHF starting on Day 4 of the disease and continuing to recover.

Background: Injury to the CNS related with perinatal asphyxia is referred to as Hypoxic-Ischemic Encephalopathy which is the utmost severe neurological condition that arises in perinatal periods. The aim is to assess clinical variables with hypoxic-ischemic encephalopathy stages. Subjects and Methods: A clinical study of 42 new borns asphyxiated were assessed clinically of these asphyxiated neonates was carried out using Sarnath and Sarnath Staging of HIE. The association between asphyxia at birth and HIE has been examined. Results: In the present study, maternal history, gestational age, and mode of delivery were found to be not significant and do not correlate with the severity of HIE. Sarnath and Sarnath clinical scoring for neurobehavioral signs and symptoms 13 (31%) had reveal of HIE stage -1, 14 (33%) are of stage -2 and severe HIE (HIE-III) common, seen in 15cases (36%). The correlation of non-stress test (NST), Meconium staining was more in stage-3 in HIE stages and statistically significant. Conclusion: During the diagnosis and treatment of HIE patients, analysis of clinical variables will improve the objectivity of newborn assessment and evaluation and early start of care.