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Secondary pancreatic tumors are uncommon, with the majority originating from primary gastrointestinal or lung cancers. We present the case of a 42-year-old woman with squamous cell carcinoma of the pancreas, found to be human papillomavirus-positive on in situ hybridization. After extensive work-up, the patient was determined to have a previously undiagnosed, asymptomatic head and neck primary malignancy. There is sparse literature discussing metastatic human papillomavirus-positive squamous cell carcinoma to the pancreas. This report highlights the importance of including this diagnosis when considering a differential for secondary pancreatic tumors, especially squamous etiology. CASE REPORTA 42-year-old woman with a history of anemia presented with 5 months of epigastric pain radiating to the back. The patient reported decreased appetite with nausea and vomiting and a 30-pound unintentional weight loss. Her epigastric pain worsened in intensity over several weeks and was associated with darkened urine. She endorsed several weeks of constipation but denied pale-colored stools or steatorrhea. The patient had a family history significant for colorectal cancer in multiple family members. She denied a history of