Introduction: Psoriasis is a chronic inflammatory immune mediated cutaneous disorder. Histologically it shows epidermal proliferation and neovascularisation in papillary dermis. Histological grading of psoriasis is done using Trozak Histological assessment Score (THS). Angiogenesis drives psoriasis. Vascular Endothelial Growth Factor (VEGF) and Cluster of Differentiation (CD34)/Micro Vessel Density (MVD) are proangiogenic cytokines in psoriasis and are overexpressed in psoriatic skin when compared to normal controls.Aim: 1) To analyse and compare the IHC expression of VEGF and CD34/MVD in skin biopsies of psoriasis cases and controls; 2) To compare the expression of VEGF, CD34/MVD with histological grade done by THS. Materials and Methods: A retrospective study was done in the Department of Pathology at Dr. BR Ambedkar Medical College and Hospital between September 2020 to August 2021. Twenty five cases and 25 controls (normal skin) were included in this study. Histopathology/Immunohistochemistry (IHC) for VEGF and CD34 was performed. Suprabasilar layers of the epidermis were assessed for VEGF expression. Cell showing granular positivity within the PARTICULARS OF CONTRIBUTORS:

Leukemic cells infiltrating the dermis are referred to as leukemia cutis. Leukemia cutis is seen in myeloid and lymphoid leukemias. Granulocytic sarcoma presenting primarily as skin nodule [leukemia cutis] in CML is a rare entity. Presence of leukemia cutis points towards blast crisis and poorer prognosis even when the hematological parameters point towards a chronic phase. The authors report a case of Leukemia cutis in Chronic Myeloid Leukemia presenting with multiple large skin nodules all over the body. The clinicopathological features of this variant with FNAC cytology, skin biopsy and histopathology findings and peripheral blood smear are discussed with full details. KEY WORDS; CML, Leukemia cutis, Granulocytic sarcoma (GS). INTRODUCTION: Leukemic cells infiltrating the dermis are referred to as leukemia cutis. Leukemia cutis is seen in myeloid and lymphoid leukemias. Leukemia cutis is a rare presentation of Granulocytic sarcoma. Granulocytic sarcoma (chloroma) is formation of localized tumor mass in any part of the body, composed of granulocytic series of cells seen in myeloid leukemias. Granulocytic sarcoma is reported in 3-9% cases of acute and chronic myelogenous leukemia (1). The authors report a case of Leukemia cutis in Chronic Myeloid Leukemia presenting with multiple large skin nodules all over the body. The clinicopathological features of this variant are discussed with full details. CASE REPORT: A 33 yr old male presented with multiple cutaneous nodules over the face, back, anterior chest wall and limbs, associated with fever for duration of 3 months. The patient was referred from the dermatology department with a provisional diagnosis of leishmaniasis for FNAC of the skin nodules. On examination the skin nodules were of varying sizes ranging from 1-5 cms, largest measuring 5x3 cms and average size being 2x1 cms. The nodules were present all over the body, more on face, back, chest wall and limbs. [Fig 1]The nodules were firm to hard and non tender on palpation. FNAC was performed at multiple sites from multiple nodules. Aspiration was

No abstract

Introduction: Tumour Associated Tissue Eosinophilia (TATE) is an important phenomenon occurring in the tumour microenvironment and has a pivotal role. TATE is defined as “eosinophilic stromal infiltration of a tumour not associated with tumour necrosis or ulceration”. The exact role of TATE in malignancies is yet unclear but studies have shown that TATE usually has a favourable outcome in head and neck Squamous Cell Carcinoma (SCC). Therefore, more studies are needed to substantiate this data. Aim: To compare TATE between normal epithelium and Oral Squamous Cell Carcinoma (OSCC) and compare TATE between the histological grades of OSCC. Materials and Methods: A retrospective study was conducted at Dr. BR Ambedkar Medical College, Bangalore, Karnataka, India, from June 2019-January 2021 which included 50 cases, 10 from normal mucosa and 40 histopathologically diagnosed cases of OSCC. 1% congo red solution was used to stain 4 μm thick sections. The sections were examined at a high magnification (40X) and 10 microscopic fields were examined in succession for eosinophils. The average number of eosinophils observed were compared using univariate analysis, which included the Analysis of Variance (ANOVA) test and the Chi- square test and a p-value of 0.001 was considered statistically significant. Results: The mean value of tissue eosinophils increased in OSCC compared to normal mucosa, according to present study findings. When comparing different grades of carcinoma, statistical analysis revealed that well differentiated squamous cell carcinoma had a greater TATE than other grades, which was statistically significant (p-value <0.001). Conclusion: The higher eosinophil count in well differentiated OSCC compared to the other grades could be associated with a better clinical outcome for the patient. In OSCC, TATE can be utilised as a predictor of a good prognosis.

No abstract