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Diabetic neuropathy (DN) is the most common microvascular complication which progressively leads to neuronal degeneration. Consequently, DN is associated with sensory symptoms such as pain, numbness, tingling, pins and needles, prickling and pinching and eventually loss of sensation. Symptoms are considered moderate to severe and may worsen at night, causing sleeping disturbs. Neuropathic pain can be constant and accompanied by cutaneous allodynia, which can affect the performance of daily activities of diabetic patients. The mechanisms that cause diabetic neuropathic pain (DNP) are not fully understood, although toxic effects of hyperglycaemia considered an important factor for the development of this complication.

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