The reaction of 2,4-bis((Z)-arylidene)dihydrothiophen-3(2H)-ones and 2-(1-arylethylidene)malononitriles proceeded through a tandem sequence of reactions in a single step affording 2-thiaspiro[4.5]deca-6,8-dienes in quantitative yields.

The combinatorial syntheses of a library of novel dihydrothiophenone-engrafted dispiro oxindole/indenoquinoxaline-pyrrolidine/pyrrolothiazole/indolizine hybrid heterocycles have been realized through a chemo-, regio-, and stereoselective multicomponent 1,3-dipolar cycloaddition strategy.

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