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In search of some antimicrobial agents, synthesis of some Schiff base of cyanoacetohydrazide derivatives has been reported. The structures of all the synthesized compounds were established on the bases of various spectroscopic methods. All Schiff base were screened for antimicrobial activity. cyanoacetohydrazide were found to possess better antimicrobial potential.

Abstract:The metal complexes of Ni(II), Cu(II), Zn(II) Cd (II) with organic ligands viz Hydrazine hydrate, 1,2-N,N -Bisammonium thiocarbamoyl ethane and 1,4-N,N -Bisammonium thiocarbamoyl benzene have been prepared. These ligands and metal complexes of dithiocarbamates were screened for their antimicrobial activity against various microbs.

Different benzaldehydes and pyridine substitution were used on 1 and 4 'N'-positions of thiosemicarbazide respectively. This substituted-benzaldehyde-2-aminopyridine-N-thiohydrazone ligand was further used to synthesize Co(II), Ni(II) and Co(II) based metal complexes and characterized by FT-IR, Elemental analysis, ESI Mass and elemental analysis. All synthesized compounds were studied for their physical properties, antibacterial and antifungal activity. In this antimicrobial study Cu(II) and Ni(II) metal complexes have shown better anti-bacterial activity. While several synthesized metal complexes have shown comparable activity with standard drugs taken.

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