The Irula community constitutes a small tribal community living in different parts of India and their main occupation is snake catching. They have rich knowledge about medicinal plants and their uses against various ailments. Snake bites are the common acute medical emergency faced by rural people. Even though Anti Venom Serum (AVS) is used as a remedy for snake bites in hospitals and in primary health centres, the rural people still depend on antidotes from medicinal plants.To counter the emergencies due to snake bites, the plants/parts of the plants are used alone or in combinations with other plants to make anti-dotes. The survey reports thirty traditional medicinal plants which are used by Irula against snake bites. These plants must contain some compounds responsible for snake venom inhibition. Venom neutralization or anti-inflammatory properties of the compounds identified from these plants have not been reported. Our present study reports the phytochemical analysis of the extracts from four plants which are commonly found and some of these compounds are identified as anti-inflammatory agents. Screened compounds are chosen for finding the binding affinity with PLA2 targets using the commercial Schrodinger software. Molecular Dynamics simulations were also carried out for the most favourable compounds and stability was checked upto 50ns.

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