Objective: The aim of this study was to gain a better understanding of the lived experiences of young-onset colorectal cancer (yCRC) from the perspective of patients and/or caregivers. Methods: We conducted a qualitative study, in collaboration with COLONTOWN®, an online colorectal cancer community. Individuals who have been diagnosed with yCRC, that is below the age of 50 years, or care for an individual with yCRC were invited to complete an online survey primarily comprising of an open-ended question asking participants to share their yCRC experiences in a text box, similar with how they may post on a social media platform. We applied an inductive, qualitative approach to identify themes arising from participants’ experiences. Results: From May to June 2019, we gathered experiences from 109 patients with yCRC and 11 caregivers. The majority of patients with yCRC were female (86, 71.7%) and diagnosed between the ages of 30 and 39 (49, 40.9%) and 40 and 49 years (61, 50.8%). We identified 8 themes: symptoms experienced; being misdiagnosed; advocating for oneself; appreciation of the healthcare team; frustration with the healthcare team and healthcare system; lasting effects of yCRC and its treatment; connecting with others; and reflections on experiences with yCRC. Conclusions: Our study highlights challenges experienced by yCRC patients across diagnosis, during treatment, and after treatment, notably misdiagnosis and need for access to information and support. Our study raises awareness of yCRC and experiences of individuals impacted by this disease.

Aims The aim of this investigation was to evaluate echocardiographic parameters of cardiac function and in particular right ventricular (RV) function as a predictor of mortality in patients with coronavirus disease‐2019 (COVID‐19) pneumonia. Methods and Results This prospective observational study included 35 patients admitted to a UK district general hospital with COVID‐19 and evidence of cardiac involvement, that is, raised Troponin I levels or clinical evidence of heart failure during the first wave of the COVID‐19 pandemic (March–May 2020). All patients underwent echocardiography including speckle tracking for right ventricular longitudinal strain (RVLS) providing image quality was sufficient (30 out of 35 patients). Upon comparison of patients who survived COVID‐19 with non‐survivors, survivors had significantly smaller RVs (basal RV diameter 38.2 vs 43.5 mm P = .0295) with significantly better RV function (Tricuspid annular plane systolic excursion (TAPSE): 17.5 vs 15.3 mm P = .049; average RVLS: 24.3% vs 15.6%; P = .0018). Tricuspid regurgitation (TR) maximal velocity was higher in survivors (2.75 m/s vs 2.11 m/s; P = .0045) indicating that pressure overload was not the predominant driver of this effect and there was no significant difference in left ventricular (LV) ejection fraction. Kaplan–Meier and log‐rank analysis of patients split into groups according to average RVLS above or below 20% revealed significantly increased 30‐day mortality in patients with average RVLS under 20% (HR: 3.189; 95% CI: 1.297–12.91; P = .0195). Conclusion This study confirms that RVLS is a potent and independent predictor of outcome in COVID‐19 patients with evidence of cardiac involvement.

The word "pornography" takes its origin from the Greek word which means "writing about harlots." The females depicted in pornography are shown as submissive, pleasing their partners and not focusing on their own pleasures. The term is in contrast to "erotica" which refers to the term in which both the partners in the act are simultaneously enjoying their sexual plays and thus give obvious focus on sensuality. 1 Pornography is defined as the portrayal of sexual subject matter for the purpose of sexual arousal using various means that includes books, magazines, drawings, videos, and video gaming. In other terms, it is the depiction of the act rather than the act itself. Peter and Valkenburg defined pornography as professionally derived or user-generated pictures or videos (clips) intended to sexually arouse the viewer. These include videos and pictures depicting sexual activities, such as masturbation, oral sex, as well as vaginal and anal penetration, in an unconcealed way, often with a close-up on genitals. 2 Soft-core and hard-core pornography are the two types which need tentative discrimination. Soft-core pornography involves the depiction of couples undressed in sexually intimate poses. The focus on genitals will be minimal in this type. In contrast, hard-core pornography, as the name suggests, involves stimulation of the other individual, penisin-vagina penetration, anal penetration, or oral stimulation. Giving explicit focus on ejaculation, group sexual activities, bestiality, and child pornography are also part of hard-core pornography.

The reported findings raise a number of interesting issues regarding the nature of hemispheric involvement in schizophrenia.

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