The finding determines the dependence of body processes on STP and MCT, six processes which occur in the isolated rabbit ileum were used to prove the statement of the theory 1 of BUTT, mainly effects of extract and Autonomic drugs on isolated rabbit ileum together with novel mathematical principles were used to show that seven normal processes (motility, secretion, metabolism, circulation, immunoreactivity, absorption, digestion) of the isolated rabbit ileum are directly proportional to activated STP and MCT and inversely proportional to inactivated STP and MCT given as, To estimate N i for each receptor in the isolated rabbit ileum, I determined number of molecules (N) for each drug and extract and number of molecules (N x ) towards the receptor direction, also using a biomarker (isolated rabbit ileum) the magnitude of effect (contraction and relaxation) of extract/drugs on the ileum was determined by combination interactions, novel mathematical equations and quantum physics, which gave me insight about the autonomic nature of the extract. Again from the combination interaction of antagonists and agonists with the extract as well as novel mathematical equation and calculation, I deduced the receptor types which combined with the extract, the couple receptor types, and the linked cascades in un limited sense of their complexity, in spite that past finding have unraveled various receptor types, limitations of characterization and crystallography abounds and so warrant use of mathematic to gain useful insight, interestingly, observed height, STP components' flux time and mathematically determined magnitude of response (R sm ), shows strong correlation, of course as found in other findings, we assumed that alternating responses seen was due to bimodal on or off switches peculiar to STPs and MCT, these act in turn to activate many targets and therefore more than two responses might have occurred as predicted from various novel equation and calculation. The seven processes investigated are; directly; motility, indirectly; secretion, epithelial protein synthesis and transluminal absorption, digestion, circulation, and immunoreactive processes respectively, as a matter of veracity, it important to state that only the result of isolated rabbit ileum motility was obtained from which other processes were inferred from perspective of STP and MCT vital cascade components using platform of mathematics, in so far as this remain the case, the principle of hypothesis was investigated and lead to the emergence of Boy'o Universal Theory of Therapy (BUTT) The result was subject to both statistical analysis and mathematical calculation, for the statistical result standard deviation was 1.05 and magnitude of response (R sm ) was 27.996 at number of active components (Nc1) of 0.7 to indicate inactivation of STPs, other values show activation, a fact that is of clinical, pharmacological, and biomedical importance.

Findings prowess of young researchers and seniors appears to have been halted by feudal policies of established global governments or academic institutions which by all manner of means make uselessness of time and effort allotted to the research enterprise during conduct of high quality research, lack of political will or technocrats petulance attitude in research institutions have evolved arrays of paper works of applicable research on shelves or on benches in store room, libraries and offices, given the magnitude of global problems and limited number of solutions, these ideas should be transformed to usable forms, the review considers, benefits of applicable research, factors that militate against research transformation from paper work to pragmatic output in government or private sector, again apt policy frame work that could give impetus to researchers at local and international faced of academic or company base research enterprise was suggested in lieu of reoccurring unending problems of mankind, presumably, effective assimilation of these institutionalized redundant contributions to the very fabric of glaring glaciers of societal problems, may in passing, create egalitarian social structure, for assuredly, I hasten not to posit that, solutions in the "stored" redundant research works are the mainstay of equitable resource distribution, this is true, if by logical verbosity, solutions in them turn resources scarcity to resource abundant, it could be surmised that all of mankind struggle consist in plethora resources, resource lack or abundance at any given period in time, consequently I show by review, measures needed to justify time, money, and energy invested in the research conduct so as to diminished societal problems to barest minimum and turn research reports to real life applicable tools.

Definition of new termsSpecial treatment room is a specially designed room in the hospital where the machine will be house. VBBI is values of strength of the immune systems following exposure to the machine, ISI is the immune strength time span. IP is immune power actual ability of immune system to fight off or attenuate an attack. AbstractThe essence of the review is to demonstrate the following, the evolution of a novel machine that could boost the body immune system, treat through hyperthermia, existing body abnormalities linked with febrilar response, and make formidable the immune system if routine weekly exposure of individuals, whether or not in ill health is done, and again the operation of the machine will focus on adjustment of bio-thermal circles pertinent to induced pyrogen (for routine treatment) and non-induce non-pyrogen (as found in ill health) such that immediate immune response effectively, could combat existing disease in addition to protecting the body against futures attacks generally. Febrile responses mediators, broadly speaking encompass dual types, pyrogens and non-pyrogen, pyrogens mediated are inducible even in absence of disease or abnormal condition, non pyrogen febrilar reponses usually emanate from disease or abnormal condition of the body (cancer, infectious disease and non infectious disease) in either case, resultant hypethermia and immune responses are secondary to altered cellular physiological processes, among them are increases or decrease in metabolism of fuels molecules of the cells, mobilisation of mineral elements iron for instance, acute phase protein mobilisation, increase in uptake of de novo synthesize survival materials (may increase life span), activations of immune system chain reaction by secretion of immunological communicants such as cytokines and chemokines, sensitization and recruitment of other immune cells, ultimately also includes interactions between autocoids and some immunes cells, and as determined by the hypothalamic thermostat leading to increase in body defence mechanism and well being. Erroneously, temperature increase is seen as fever, however on the contrary, hyperthermal events is just one among many of it manifestations, for actually fever is systemic attempts to fight off pathological or abnormal attacks in the internal milieu, past finding adduced that fever is associated with many disease or abnormality, a fact that depict a need for further research on survival value of fever, it has survival value (Kluger 1998), results obtained using mathematical methods in a novel way from previous finding results and standard reference physioantobiochemical values were analysed with SPSS analytical package, dependent variables (Immune Strength Index (ISI), Values of Boosted Body Immunity (VBBI), PARPS, Survival values, Life span increase) and independent variables (incremental values of febrile temperature values of pyrogen used, number of exposure to the machine) show strong correlation P ≤ 0.005, temperature and survival value (increase in life span)...