Background: The use of pedicle screw fixation for management of various spinal disorders has become popular worldwide in recent years. Pedicle screw fixations has implications in spinal fusion by transpedicular screw insertion to achieve stability in various spinal disorders such as, fractures, scoliosis, spondylosis thesis, tumours and iatrogenic or degenerative spinal instability. It is essential for the spine surgeon to have a comprehensive knowledge of the spinal morphometric dimensions since misplacement of the pedicle screw carries significant risk for the patient. It is challenging to perform pedicle screw fixation technically due to complex anatomy. Objective: To assess the lumbar pedicle morphometry in south Indian population based on CT scans. Materials and Methods: The present prospective observational study was carried out by the department of Orthopedics at JSS Medical College, Mysore from November 2018 to September 2020. A total of 100 patients who underwent Computed tomography of lumbar spine and Computed tomography abdomen and pelvis in JSS Hospital, Mysuru during the study period were included in the study. Results: The mean transverse pedicle Isthmus width was the least at L1 level (6.64mm) and highest at L s level (15.66mm). There was significant difference between male and female Vertebral Diameters.

Flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), which may treat hypoactive sexual desire disorder (HSDD) in women. Women with HSDD have a chronic lack of interest in sex that cannot be explained by another medical condition. Feelings of distress also accompany HSDD. Mechanism of action of flibanserin is different because it works on a women’s brain. Flibanserin works on three necessary brain chemicals: dopamine, norepinephrine, and serotonin. It acts as a dual control model of sexual response. Various neurotransmitters, sex steroids, and other hormone effects on the sexual response with significant excitatory and inhibitory effects. Among neurotransmitters, dopamine and norepinephrine stimulate activity, while serotonin inhibits activity and the balance between before discussed systems are of significance for a healthy sexual response. By modulating serotonin and dopamine activity in some regions of the brain, flibanserin can enhance the equilibrium of sexual response balance between these neurotransmitter systems. The significant side effects of flibanserin are dizziness, sleepiness, nausea, feeling tired and trouble sleeping. Simultaneous consumption of alcohol and flibanserin may result in severely low blood pressure.