Retinoblastoma is one of the common intraocular malignancy in childhood. It’s incidence varies between 1 in 3300 to1 in 20,000 live birth. Retinal dysplasia is a rare disorder which can mimic retinoblastoma. Retinal dysplasia is a rare cause of childhood leucocoria, which can cause considerable diagnostic difficulty in the differentiation of benign and malignant intraocular pathologies Enucleation is often required for both these conditions. In this series we are discussing 4 cases of enucleated eyeball. Out of these 4 cases three cases were of retinoblastoma.4 case was done for post traumatic phthysis bulbi. In this case series we are discussing diagnostic and prognostic indicators of Retinoblastoma as well as retinal dysplasia.

Background: Prostate cancer represents the second most frequently diagnosed malignancy among the male and fth leading cause of death. Tumour grade is one of the most important prognostic factors of prostate cancer. There are many markers studied in prostatic cancers, but the most extensively studied one is Ki-67, the proliferative marker. Prostatic cancers with Ki-67 over expression are generally aggressive. Aim And Objectives: - Aim of this study is evaluate ki67 immunoexpression in adenocarcinoma of prostate and to correlate with histopathological grade (Gleason Grade). This is single centre cross sectional study. The patie Material Methods:- nt who visited department of urology and renal transplant in Gauhati medical college and hospital and whose TRUS guided biopsy were received in the pathology department and diagnosed as adenocarcinoma were included. A total 50 cases were analysed. Tumour grade was determined according to Gleason's grading system and Ki-67 expressions were determined by IHC staining. The obtained results were analysed and evaluated using Chi square test (IBM SPSS version 21). Result And Interpretation:- A statically signicant correlation found between Gleason Grade and Ki-67 immuno expression with a p value of <0.001. In this study a statistically signicant correlation was found between Conclusion: - Gleason Grade and ki-67 labelling index. Hence Ki-67 immunoexpression evaluation and its result can be incorporated with histopathology which may inuence clinical decision making as prognosis of prostate cancer.

Background: The oral squamous cell carcinoma (OSCC) is the most common cancer worldwide and constitute a major health problem in developing countries, representing the leading cause of death. The oral cavity can be involved by a variety of lesions. These can be benign, premalignant or malignant. The most common carcinogenic agents associated with oral cavity lesions are tobacco, alcohol and betel nut (pan). Aims and Objectives: 1. early detection of premalignant and malignant oral lesions. 2. To conrm the cytological ndings by histopathological examination scrapped smear from 115 cases of oral cavity lesions were prepared and stained with MG Materials and Methods: G and PAP for cytological examination. The specimen/ biopsy material from oral cavity was collected, xed in 10% formalin and stained with H&E for Histopathological examination. July 2021 to June 2022. Out of 115 cases 23 were non- ne Study period: Results: oplastic, 22 cases were premalignant (dysplasia) and 70 cases were malignant in cytological examination. Overall, the scrape cytology diagnosis was concordant with nal histopathological diagnosis in 109 cases out of 115 cases with diagnostic accuracy 94.78%. The sensitivity was 92.11% and specicity was 100%. Oral scrape cytology is a rapid, painless, safe, inexpensive method for screeni Conclusion: ng and can diagnose a large number of patients in a short time. This method can be used for mass screening of population.