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New strategies have been developed to design advanced functional biomimetic structures. This paper reviewed the benefits and drawbacks of biomaterials that are used to manufacture 3D scaffolds in tissue engineering. In this paper, latest technological methods, scaffold requirements in development of single form, composite form and cell-laden based scaffolds, classification on the basis of geometry and main material is explained elaborately. These scaffolds promote different molecules can be delivered to tissue and stimulate cell growth. These cells have a therapeutic effect. The paper discusses the various 3D bio printed structures and the difficulties they encounter. The impacts of biologically functionalized biomaterials on soft and hard tissue engineering in vitro and in vivo are discussed. The paper summarized the future prospects for bioactive scaffolds, that can be used in clinical therapy.

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