Alzheimer's disorder is one of the maximum devastating mind problems of aged humans It is an undertreated and under-identified disorder this is turning into a chief public health problem. The remaining decade has witnessed a progressively growing attempt directed at discovering the etiology of the disease and developing pharmacological treatment An overview of Alzheimer's as a disease state and its pharmacological and non-pharmacological management is provided in the paper. Caring for the person diagnosed with Alzheimer's may be taxing and thus caring for the carer is also described. Currently to be had remedies i.e. Acetylcholinesterase inhibitors (rivastigmine, galantamine, donepezil) and N-methyl d-aspartate receptor antagonist (memantine) contribute minimal impact on the disease and target late aspects of the disease. These tablets slow down the development of the disease, offer symptomatic relief but fail to achieve a definite cure.

Type 2 diabetes mellitus is characterised via way of means of insulin resistance and innovative β mobileular Failure; therefore, β mobileular secretagogues are beneficial for attaining enough glycemic control. Glimepiride is a second-era sulfonylurea that stimulates pancreatic β cells to launch Insulin. Additionally, is has been proven to paintings thru numerous more pancreatic mechanisms. It Is administered as monotherapy in sufferers with kind 2 diabetes mellitus in whom glycemic Control isn’t executed with the aid of using nutritional and way of life modifications. It also can be mixed with different Antihyperglycemic agents, such as metformin and insulin, in sufferers who aren’t safely Controlled with the aid of using sulfonylureas alone. The powerful dosage variety is 1 to eight mg/day; however, There isn’t any extensive distinction among four and eight mg/day, however it ought to be used with warning In the aged and in sufferers with renal or hepatic ailment. In scientific studies, glimepiride became Generally related to decrease threat of hypoglycemia and much less weight advantage as compared to different sulfonylureas. Glimepiride use can be more secure in sufferers with cardiovascular ailment due to its loss of adverse results on ischemic preconditioning. It is powerful in lowering fasting plasma glucose, post-prandial glucose, and glycosylated hemoglobin tiers and is a useful, cost-powerful remedy alternative for handling kind 2 diabetes mellitus.