During storage, stored commodities are attacked by different kinds of insect pests. Among these storage insect pests, Rhyzopertha dominica Fab. is one of the most threatening pest. The present study was carried out at Grain Research, Training and Storage Management cell of the Department of Entomology, University of Agriculture, Faisalabad. Acetone extracts of Nicotiana tabacum and Piper nigrum at a concentration of 10, 15 and 20% and new chemistry insecticides Spinosad at concentrations of 1, 1.5 and 2ppm were evaluated alone and in combination for their mortality effect against R. dominica. The results revealed that spinosad showed more mortality than other two plant extracts of P. nigrum and N. tabacum. Spinosad showed maximum mortality 44.44% at the exposure time of 72hrs and minimum mortality of 4.83% at 24hrs exposure period. While in case P. nigrum showed the less mortality than spinosad and the N. tabacum. The application of P. nigrum was resulted into 1.67 and 5.42% mortality after exposure period of 24 and 72 hrs, respectively. The application of N. tabacum has been resulted into 23.75 and 2.34%mortality after 72 and 24hrs of treatment. It was also obvious from the results that a direct concentration and mortality response was observed in all the treatment applications. The results regarding the combine effect of plant extract and spinosad showed that the maximum mortality 57.73% was by the combinations of all three treatments of new chemistry insecticide and plant extracts. While mortality was minimum 28.73% where plant extract was applied only. From these results it was concluded that new chemistry insecticides had high toxicant action as compared to plant extracts against R. dominica and could be recommended for the management of stored grain pest R. dominica.