UACR was the kidney biomarker most strongly associated with risk of incident stroke. Results in this elderly cohort may not be applicable to younger populations. These findings suggest that measures of glomerular filtration and permeability have differential effects on stroke risk.
An observational descriptive study was carried out of the healthcare resources consumed during 1 year by a sample of patients with type II diabetes of a healthcare area in southern Spain. A total of 517 patients with a mean duration of disease of 9.7+/-8 years were assessed. A total annual health cost of 4,278 euro/patient was calculated (direct 2,504 euro; indirect 1,774 euro). Multiple regression analysis showed an independent association between total costs and obesity, male sex, number of hospitalizations related to diabetes, permanent disability, macrovascular complications, and both micro- and macrovascular complications. Our findings confirm both the high economic cost associated with type II diabetes and the direct relationship between the costs of the disease and the presence of obesity, male sex, hospitalizations related to diabetes, permanent disability and chronic complications.
B lymphocytes that infiltrate the thyroid (Thy-B cells) in Graves' patients appear to be implicated in the pathophysiology of this disorder. The goal of the present study was to examine the nature of these Thy-B cells. To this end, Thy-B lymphocytes were isolated from surgical thyroidal samples, and their phenotype was determined by using mouse monoclonal antibodies (mAb) directed against a wide variety of surface markers, followed by flow cytometry multicolor analysis. The results show that most Thy-B cells (approximately 60%) exhibited IgM(+) IgD(low to -) surface immunoglobulin (Ig) profile, whereas the minor cell fraction (approximately 30%) consisted of switched IgG(+) memory B lymphocytes. Thy-B cells expressed low levels of CD5, CD23, and CD62L, which distinguished them from the resting B-cell pool, the major B-cell subset in the blood. In addition, they lacked CD38, CD10, and CD71, characteristic molecules for the germinal center B lymphocytes. In addition, Thy-B lymphocytes showed peculiar patterns both of adhesion molecules (CD62L(-), CD44(intermediate)), and of activation molecules (CD69(+), CD80(+), and, in part, CD95(+)). Taken together, these results suggest that the Thy-B lymphocyte subset consists of a combination of IgM(+) B cells resembling marginal zone B lymphocytes, and isotype-switched memory B cells.
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