A numerical approach based on plastic crack tip opening displacement (CTOD) was followed to study fatigue crack growth (FCG) from notches. The identification of fundamental mechanisms was made considering notched and unnotched models, with and without contact of crack flanks. Different parameters were studied, namely, notch radius, crack length, stress state, and material. The notch increases the plastic CTOD, and therefore fatigue crack growth rate, da/dN, as expected. The reduction of notch radius increases da/dN but reduces the notch affected zone. Ahead of the notch affected zone, da/dN increases linearly with crack growth, with a rate that increases linearly with the plastic CTOD. The crack closure phenomenon has a dramatic effect under plane stress conditions but a limited effect on plane strain conditions. In the former case, the contact of crack flanks reduces substantially the effect of notch radius and the size of the notch affected zone. These trends are associated with the increase of crack closure level with notch radius. The material does not affect the global trends, but the reduction of yield stress increases the level of plastic deformation and therefore da/dN. The effect of material, and also of stress state, is mainly associated with crack closure.