1.1. Background: Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics 1.2. Objective: The genetics of BRCA-1/2 gene mutations and their impact on women have been reviewed. Methods:We reviewed the publications in PubMed, Web of Science, Scopus, related to mutations of the BRCA-1/2 genes and hereditary cancers, to assess prevention, detection and management and how to improve quality of life 1.3. Results: increased use was identified of tests, as well as risk-reducing surgery, the use of new screening strategies; Still, there is no effective detection protocol that has been shown to reduce mortality, only risk-reducing surgery, such as mastectomy and bilateral salpingo-oophorectomy; recommended after parity satisfied, has improved chemoprevention and reproductive capacity. Conclusions:Identification of women who carry a pathogenic mutation in high-risk BRCA-1/2 genes; the clinical management, prevention and identification of related cancers improves the morbidity and mortality of these patients of their individual risk clinicsofoncology.com