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The study was conducted to evaluate the alternations on haemato-biochemical profiles following administration of atropine-buprenorphine-propofol anaesthesia in six healthy non-descript goats of either sex weighing between 20-25 kg by administrating atropine sulphate @ 0.04 mg/kg I/M followed by buprenorphine @ 10 mg/kg I/M and 10 min. later induction of anaesthesia with propofol @ 5mg/kg I/V. Hb, PCV and TLC showed non-significant decrease at 60 min. however, the following values showed increasing trends at different time intervals of observation and returned to near base value by 6 hrs. There was significant (P<0.05) increase in neutrophils with significant (P<0.05) decrease in lymphocyte values. Serum glucose showed significant (P<0.05) elevation at 60 min. after atropine-buprenorphinepropofol administration whereas non-significant increase in serum urea nitrogen, serum creatinine, AST and ALT were observed at different time intervals. However, these changes were within normal physiological limits. Therefore, it can be concluded that atropine-buprenorphine-propofol combination does not produce any deleterious effect on vital organs and changes remain within physiological limits, thus can be safely used in goats.