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In this paper first examples for global thermal modeling of microgravity experiments in the field of crystal growth and alloy solidification are presented. The software program CrysVUn is used to simulate alloy solidification experiments carried out in TEXUS sounding rocket missions. Based on this software global thermal models are developed for the furnace inserts Low Gradient Furnace (LGF) and Solidification and Quenching Furnace (SQF) to be operated in the Materials Science Laboratory (MSL) onboard the International Space Station (ISS). These models will be used in order to optimize the process conditions and cartridge designs for the experiments to be carried onboard the ISS