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BackgroundDiabetic retinopathy is the leading cause of blindness in economically active populations. The aims of this study were to estimate the prevalence and to identify risk factors for diabetic retinopathy in patients with type 1 diabetes in Brazil.MethodsThis was a nationwide, cross-sectional study conducted between August 2010 and August 2014. The study included 1760 patients with type 1 diabetes. Patients underwent a standard questionnaire, clinical and laboratory analyses and were screened for diabetic retinopathy. To analyze the risk factors related to diabetic retinopathy, two models of logistic regression models were performed, one considering vision-threatening cases and the other with any diabetic retinopathy cases as dependent variables. The group with vision-threatening included patients with severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy and macular edema.ResultsIn total, 1644 patients (mean age, 30.1± 12.0 years; duration of diabetes, 15.3 ± 9.3 years; female, 55.8%) were studied. 35.7% presented diabetic retinopathy and 12% presented vision-threatening diabetic retinopathy. Three risk factors associated with diabetic retinopathy were in common to both groups: longer diabetes duration (OR 1.07; 95% CI, 1.05–1.09), higher levels of HbA1c (OR 1.24; CI, 1.17–1.32) and higher levels of serum uric acid (OR 1.22; CI, 1.13–1.31) (p < 0.001 for all comparisons).ConclusionThe higher rate of vision-threatening retinopathy found in our study highlights the need to improve access to eye care and screening programs for diabetic retinopathy in Brazil. In addition to traditional risk factors, we found an association between serum uric acid levels and diabetic retinopathy. Further studies are needed to address this association.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-5859-x) contains supplementary material, which is available to authorized users.

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Planchón-Peteroa volcano started a renewed eruptive period between January 2010 and July 2011. This eruptive period was characterized by the occurrence of 4 explosive eruptive phases, dominated by low-intensity phreatic activity, which produced almost permanent gas/steam columns (200-800 m height over the active crater). Those columns presented frequently scarce ash, and were interrupted by phreatic explosions that produced ash columns 1,000-3,000 m height in the more intense periods. Eruptive plumes were transported in several directions (NW, N, NE, E and SE), but more than half of the time the plume axis was 130-150° E, and reached a distance up to 638 km from the active crater. Tephra fall deposits identified in the NW, N, NE, E and SE flanks covered an area of 1,265 km2, thickness variable from 4 m (SE border of active crater) to ~0.5 cm 36.8 km SE and ~8 km NW from active crater, respectively, corresponding to a minimum volume of 0.0088 km3. Tephra fall deposit is exclusively constituted of no juvenile fragments including: lithics fragments as main component, quartz and plagioclase crystals, some oxidized lithics, and occasional presence of Fe oxide, and less frequently Cu minerals, as single fragments. We present new field-based measurements data of the geochemistry of gas/water from fumaroles and acid crater lakes, and fall deposit analysis, that integrated with the eruptive record and GOES satellite data, suggests that the eruptive period 2010-2011 has been related to an increasing of heat and mass transfer from hydrothermal-magmatic reservoirs, which would have been favoured by the formation and/or reactivation of cracks after 8.8 Mw Maule earthquake in February 2010. This process also allowed the ascent of fluids from a shallow hydrothermal source, dominated by reduced species as H2S and CH4, during the entire eruptive period, and the release of more oxidizing fluids from a deep magmatic reservoir, dominated by acid species as SO2, HCl and HF, increasing strongly after the end of the eruptive period, probably since October 2011. The eruptive period was scored with a magnitude of 3.36, corresponding to a VEI 1-2.