Microglial cells play essential volume-related actions in the brain that contribute to the maturation and plasticity of neural circuits that ultimately shape behavior. Microglia can thus be expected to have similar cell sizes and even distribution both across brain structures and across species with different brain sizes. To test this hypothesis, we determined microglial cell densities (the inverse of cell size) using immunocytochemistry to Iba1 in samples of free cell nuclei prepared with the isotropic fractionator from brain structures of 33 mammalian species belonging to males and females of five different clades. We found that microglial cells constitute ;7% of non-neuronal cells in different brain structures as well as in the whole brain of all mammalian species examined. Further, they vary little in cell density compared with neuronal cell densities within the cerebral cortex, across brain structures, across species within the same clade, and across mammalian clades. As a consequence, we find that one microglial cell services as few as one and as many as 100 neurons in different brain regions and species, depending on the local neuronal density. We thus conclude that the addition of microglial cells to mammalian brains is governed by mechanisms that constrain the size of these cells and have remained conserved over 200 million years of mammalian evolution. We discuss the probable consequences of such constrained size for brain function in health and disease.

Este estudo avalia a introdução do Programa de Navegação do Paciente (PNP) em uma comunidade do município do Rio de Janeiro. Os objetivos são: estabelecer a viabilidade do PNP nesse contexto; identificar as barreiras ao rastreamento mamográfico; e assegurar cobertura mamográfica de 70% das mulheres recrutadas entre 50 e 69 anos. De março a setembro de 2018, foram recrutadas 678 mulheres com idade média de 58 anos da comunidade do Andaraí. O acompanhamento foi realizado pelo navegador de pacientes (NP) por telefone, e-mail e mensagens de texto. Doze por cento das mulheres recusaram-se a participar do PNP por razões culturais. As principais barreiras relatadas pelas mulheres foram: problemas do sistema com programação de cuidados de saúde (100%), problemas financeiros (64%), preocupações relacionadas à comunicação com a equipe médica (58%), medo (44%) e apoio social (14%). Foram obtidos 100% de satisfação com o PNP, e a meta de taxa de cobertura mamográfica foi superada, atingindo o percentual de 88%. O NP promoveu aumento na taxa de cobertura mamográfica, auxiliou na transmissão de informações de qualidade, reduziu o medo da mamografia e facilitou o acesso aos cuidados de saúde da mama. ABSTRACTThis study evaluates the Patient Navigation Program (Programa de Navegação do Paciente -PNP), which was introduced to a community in the municipality of Rio de Janeiro. The objectives were: to establish the viability of the PNP in this context; identify barriers to mammogram screening; and ensure mammogram coverage for 70% of women recruited between 50 and 69 years old. From March to September 2018, 678 women with an average age of 58 years old were recruited from the Andaraí community. Follow-up was performed through the patient browser (PB), by telephone, email and text messages. Twelve percent of women refused to participate in the PNP for cultural reasons. The main barriers reported by women were: systematic problems with health care programming (100%), financial problems (64%), concerns about communicating with medical staff (58%), fear (44%), and social support (14%). The PNP obtained 100% satisfaction, and the mammogram coverage rate goal was exceeded, reaching 88%. The PN promoted an increase in the rate for mammogram coverage, aided in the transmission of quality information, reduced individuals' fear of mammography, and facilitated access to breast health care.

common in patients who presented acute seizures (frequency of 65%) and happened in 16,7-23,9% of all patients with AIS. Epilepsy was also high in patients with AIS and early-onset seizures (60% of cases) and happened in about 13-15,4% of all cases. Epilepsy showed little correlation with acute seizures in AHS. Later seizures, epilepsy in AIS were related with larger strokes. Early seizures in AIS was frequent in younger ages (3.4 ± 3.9 years) and in cortical involvements. Development of epilepsy in neonates with cerebral sinovenous thrombosis reached 18%. Conclusion: The outcomes of strokes in children are an understudied subject and few articles, researches are available. Nevertheless, an acute seizure seems to be a risk factor for future development of epilepsy.

e13104 Background: This research project aims to study the increase of mammographic coverage rate with Patient Navigation Program (PNP) in a community of Rio de Janeiro. The general objective is to measure adherence to Ministry of Health’s recommendations for breast cancer screening with mammography, with the help of a patient navigator. Other objectives include: (1) establish the viability of the PNP in this context; 2) identify the barriers to mammography screening and; 3) ensure that at least 70% of women recruited between 50 and 69 years of age and asymptomatic update the biennial mammographic examination and annual clinical examination, increasing the mammographic coverage from 14% to at least 70% considered acceptable by the World Health Organization. Methods: From March to September 2018, women from the Andaraí Community were recruited in the Municipality of Rio de Janeiro. The follow-up was carried out by telephone, e-mail, and text messages. Of the 678 women (average age = 58), 12% of women refused to participate in the PNP for cultural reasons. Results: All 599 women participants reported barriers to obtaining breast health care with the number of barriers reported ranging from 1 to 6 barriers, (average = 3). The main barriers were system problems with health care programming (100%), financial problems (64%), communication concerns with the medical staff (58%), fear (44%), and social support (14%). We obtained 100% satisfaction with the PNP and exceeded our goal with 88% mammographic coverage rate. Conclusions: The PNP for breast cancer in the Andaraí Community has proven to be feasible in the context of local public health. The PNP promoted an increase in the mammographic coverage rate to 88%, assisted in the transmission of quality information, reduced the fear of mammography, and facilitated access to breast health care. Clinical trial information: 70832117.8.0000.5279.

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