Purpose:To assess intraperitoneal adhesion formation in rats after the single implantation of intraperitoneal polypropylene mesh versus SIS mesh, and the effect of PAF as a polypropylene mesh barrier. Methods: A total of 55 albino rats randomized into three groups were assessed. The type of adhesions, the percentage of mash covered with adhesions, and the rupture strength of the adhesions were evaluated. Results: The type 2 and 3 adhesions were more frequent in group 1 (polypropylene mesh) and group 3 (Polypropylene+PAF), while type 0 and 1 adhesions were more frequent in group 2 (SIS). The mean rupture strength was 1,58 N (±0,719N) in group 1, 0,42 N (±0,432N) in group 2 and 1,23 N (±0,432N) in group 3. Over 50% of the mash was covered with adhesions in 12 (80%) cases of the group 1, in 4 (20%) cases of the group 2 and in 16 (84,2%) cases of the group 3. Group 2 differed significantly (p<0.001) from the other groups. Conclusions: Implantation of intraperitoneal polypropylene mesh yielded higher rates of adhesion and the use of PAF as a mesh barrier didn't reduced the rates of adhesion. SIS mesh implantation revealed lower rates of peritoneal adhesions. Key words: Polypropylenes. Surgical Mesh. Intraperitoneal Adhesions. Rats. RESUMOObjetivo: Avaliar a formação de aderência intraperitoneal em ratos após o implante peritoneal da tela de polipropileno comparada à tela de SIS, e o efeito do PAF como barreira anti-aderente à tela de polipropileno. Métodos: 55 ratos albinos foram randomizados em três grupos. O tipo de aderência, o percentual de tela coberta por aderência, e a força de rupturas das aderências foram avaliadas. Resultados: Os tipos de aderência 2 e 3 foram mais freqüentes no grupo 1 (polipropileno) e no grupo 3 (polipropileno+PAF); as do tipo 0 e 1 foram mais freqüentes no grupo 2 (SIS). A força media de ruptura foi de 1,58N (±0,719N) no grupo 1, 0,42N (±0,432N) no grupo 2 e 1,23N (±0,432N) no grupo3. Mais de 50% da tela estava coberta por aderências em 12 (80%) casos do grupo 1, em 4 (20%) casos do grupo 2 e em 16 (84,2%) casos do grupo 3. O grupo 2 foi significativamente diferente (p<0.001) dos outros grupos. Conclusões: O uso intraperitoneal da tela de polipropileno levou a elevados índices de aderência, e o uso de PAF como barreira anti-aderente não reduziu os índices de aderência. O implante intraperitoneal de SIS revelou índices baixos de aderências peritoneais. Descritores: Polipropilenos. Telas Cirúrgicas. Aderências. Ratos.

Acute appendicitis (AA) is the first cause of emergency surgery. Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) has been shown to be a potential biomarker in cases of AA in children, but there are conflicting results for its use in adults. The objective of this study is to compare the median plasma values of LRG1 in patients with acute abdomen with and without appendicitis. This case–control study was conducted prospectively at the emergency room (ER) of a tertiary teaching hospital, between March 1st, 2011 and December 31st, 2012. Patients with recent abdominal pain, aged 18–70 years who attended at the ER were included in the study. Blood samples were drawn at the first presentation. Those who were submitted to surgery and had a pathology report of AA were considered as cases. Those without a need for surgery and treated for other conditions, e.g., pelvic inflammatory disease, were considered as controls. Follow-up in controls was made up to 30 days. LRG1 plasma median values were measured using an ELISA kit and compared between groups. A total of 28 participants, 14 cases with acute appendicitis and 14 controls, were included. The median (range) values of leucine-rich alpha-2-glycoprotein-1 level in the group with appendicitis and control group were 8.8 ng/ml (5.5–31) and 11 (4.6–108) ng/ml, respectively (Mann–Whitney test P = 0.26). Median plasma leucine-rich alpha-2-glycoprotein-1 levels were not useful in diagnosing Acute Appendicitis in patients with acute abdominal pain.

The combined use of polypropylene mesh and lactic acid bioprotector showed similar results in relation to intraperitoneal adhesion formation when compared to the sole use of the same mesh.