Lipid propofol and propofol nanoemulsion were equivalent concerning effectiveness, safety and adverse effects in the doses used. There was a lower incidence of pain on injection in the nanoemulsion formulation.

Summary: Rodrigues TA, Alexandrino RA, Kanczuk ME, Gozzani JL, Mathias LAST -A Comparative Study of Non-Lipid Nanoemulsion of Propofol with Solutol and Propofol Emulsion with Lecithin.Background and Objectives: Some formulations have been proposed to reduce the adverse reactions due to the lipid emulsion containing soybean oil used as propofol carrier. This study for endoscopy sedation was aimed at evaluating and comparing the safety, effectiveness and adverse effects of the use of propofol nanoemulsion compared to propofol currently commercialized.