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Collectively, our results indicated that PDT-Photogem(®) can act in glioma cells, thus encouraging new experiments in this field.

Immunoexpression of endothelial NO synthase (eNOS) and inducible NOS (iNOS) was also accessed. RESULTSThe endothelium-dependent relaxation induced by ACh was decreased in CSM from ethanol-diabetic rats when compared with the controls, with a mean ( SEM ) of 21 (4) vs 37 (2)%. Similarly, the potency and maximal responses induced by SNP were reduced in the ethanol-diabetic [3.97 (0.38) and 85 (1)%, respectively] and diabetic groups [3.78 (0.56) and 81 (2)%, respectively] when compared with the controls [5.3 (0.22) and 90 (3)%, respectively] and isocaloric [5.3 (0.19) and 92 (1)%, respectively] groups. Noradrenergic nerve-mediated contractions of CSM in response to EFS were increased in rats from ethanol-diabetic and diabetic groups when compared with the control and isocaloric groups. Conversely, there were no differences in EFS-induced relaxation among the groups. The immunostaining assays showed overexpression of eNOS and iNOS in the CSM from diabetic and ethanol-diabetic rats when compared with the control and isocaloric rats. CONCLUSIONThere was an impairment of relaxation of CSM from ethanol-diabetic and diabetic rats that involved a decrease in the NO-cyclic guanosine monophosphate signalling pathway by endothelium-dependent mechanisms accompanied by a change in the CSM contractile sensitivity.

The Calcifying Cystic Odontogenic Tumor (CCOT) was first described by Gorlin in 1962. Due to its clinical, radiographic, and histopathological variables, it presents a wide variety of terminologies. The present report presents an extraosseous lesion (unrelated to teeth) with totally atypical behavior and a large bone resorption area. Clinical examination revealed a slight bulging in the lower right region of the jaw, presenting pain on palpation and soft consistency, as well as liquid contents inside it. A panoramic radiograph evidenced the presence of large local bone resorption. After collection of the material for histopathological analysis, the diagnosis was calcifying odontogenic cystic tumor. The lesion is also known as oral tumor of Malherbe, atypical Case Study ameloblastoma, keratinizing ameloblastoma, ghost cells odontogenic carcinoma, and Gorlin's cyst. Such diagnosis in the literature is important, as there is a wide variety of manifestations of these lesions, complicating the clinical diagnosis and the terminological standardization of the disease.