This prospective consecutive observational study describes the blood levels of macrophage migration inhibitory factor (MIF), other cytokines, and markers of acute-phase response in 49 consecutive patients who developed the clinical syndrome of sepsis after cardiac surgery. Before starting antimicrobial treatment, all patients underwent microbiologic screening, and blood samples were collected. These samples subsequently were assayed for MIF, macrophage chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and -10, procalcitonin (PCT), and C-reactive protein (CRP). Patients with positive cultures (n = 25) had a higher mortality (P = 0.046) and higher levels of MIF (P < 0.001) than those with negative cultures (n = 24). We could not detect significant difference between the groups concerning the levels of CRP, PCT, IL6, IL10, MCP-1, or TNF-alpha. MIF levels showed an area under receiver operator curve of 0.823 for the prediction of culture-proven bacterial infection, with the best cut-off value at 988.5 pg/mL. In conclusion, circulating levels of MIF could be indicated as a valuable marker of microbiologically documented sepsis in patients after cardiac surgery, which suggests that MIF may be prospectively explored as a useful diagnostic tool in this setting.
SummaryBackground: Quality indicators (QI) for cardiac surgery are important instruments for measuring healthcare quality in hospital centers and allow comparison with high-quality healthcare centers.
O artigo não é sobre Heidegger, mas sobre a coisa do pensar, para a qual ele acenou. A meditaçãoprocura pensar o relacionamento entre o pensar e o ser tal como se dá na dimensão da facticidade eda existência do humano, que é, ele mesmo, um abismo. O pensar se mostra como espera doinesperado e como memória criativa. A espera do inesperado não é um adiar do pensar, mas simuma insistência na serenidade da clareira do ser. A memória criativa é memória do porvir econcentração do pensamento que busca resgatar no pensado o impensado. O pensar dopensamento de até agora se erige como representação. A sua finitude, porém, testemunha o toque eo apelo do ser. O ser, no pensar de até agora, se deu como parousía, isto é, como advento à presençae como vigência atual, do presente. O traço fundamental do ser repousa no desencobrimento e naatualidade. O outro pensar, porém, que se dispõe ao outro princípio e à principialidade, éreivindicado, possibilitado e pro-vocado e conduzido ao seu próprio desde o abismo do mistério doser.
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