No abstract

In our experimental model, bone marrow-derived mesenchymal stem cells injection improved muscle regeneration and increased contractile function of anal sphincters after injury and repair. Therefore, mesenchymal stem cells may represent an attractive tool for treating anal sphincter lesions in humans. Investigations into the biologic basis of this phenomenon should increase our knowledge on underlying mechanisms involved in sphincter repair.

A semi-synthetic screening method for mining the biodiversity of [FeFe]-hydrogenases, expanding the toolbox for biocatalytic H2-gas production.

The mechanism of hydrogen gas formation by [FeFe] hydrogenase is probed under whole cell conditions, revealing the formation of reactive metal hydride species under physiologically relevant conditions.