Renal Cell Carcinoma (RCC) corresponds to 3% of the neoplasms in the adults. Surgery is the main mode of treatment, which can be associated toretroperitoneal lymphadenectomy in the presence of clinically tumor positive lymph nodes. Castleman Disease (CD) is a rare lymphoproliferative disorder, with little-known etiopathogenesis. It rarely affects the retroperitoneum. Thorax, neck, and abdomen are more frequently affected. Therefore, CD can simulate lymphatic spread from RCC to the retroperitoneum, also leading to a possible misdiagnosis, or diagnosis concerning a paraneoplastic syndrome due to RCC.

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Penile carcinoma is rare neoplasm in western countries. In development countries can constitute more than 10–20% malignant disease in men. It is usually seen in men with poor standards of penile hygiene. The bot fly (Dermatobia hominis) is endemic in certainly regions such as Central and South America. Human infestation at nonendemic areas is difficult to diagnose and the penile localization is rare and makes the diagnosis more difficult. The authors describe a rare case of simultaneous association between penile carcinoma and myiasis treated both surgically.

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