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Resumo: O objetivo deste estudo foi avaliar a estabilidade acelerada de duas formulações magistrais de cetoconazol xampu, determinar seu prazo de validade e comparar estes resultados com as formulações industrializadas. Utilizouse o medicamento referência, um genérico e um similar, além de duas formulações manipuladas, todas contendo cetoconazol na concentração de 2%. As amostras foram armazenadas em 4°C, 25°C e 40°C + 70% UR por 180 dias e avaliadas em relação a cor, odor, densidade, viscosidade e teor, conforme a Farmacopéia Brasileira. Todos os produtos foram aprovados nos testes de identificação, volume médio e doseamento. As formulações comerciais praticamente não sofreram alterações de cor e odor quando armazenadas a 4°C e 25°C, já os medicamentos manipulados mantiveramse estáveis a temperatura de 4°C, mas quando armazenadas a 25°C sofreram pequenas alterações de cor, próximo aos 180 dias. Não houve alterações consideráveis de pH e densidade, em todas as amostras. Foi impossível determinar a faixa ideal de viscosidade. Os medicamentos comerciais e a formulação 1 mostraram boa estabilidade, sendo possível conseguir um prazo de validade provisório de 24 meses.Descritores: Estabilidade cetoconazol, Produtos Manipulados, Xampu. Accelerated stability study of shampoo formulations containing ketoconazole 2%Abstract: This study had the objective to evaluate the stability of two accelerated magistral formulations of ketoconazole shampoo, determine its validity and to compare the results with the formulations industrialized. Was used the drug reference, a generic and a similar, besides the manipulated formulations, all containing ketoconazole at a concentration of 2%. The samples were stored at 4°C, 25°C and 40°C + 70% UR, for 180 days and evaluated for color, odor, density, viscosity and dosage. All products have passed the tests for identification, dosage and medium volume. The commercial formulations virtually unchanged in color and odor when stored at 4°C and 25°C, and manipulated formulations remained stable at a temperature of 4°C, but when stored at 25°C began to experience minor changes in color, close to 180 days. No significant changes on pH and density for all samples were observed. Was impossible to determine the optimal range of viscosity. The commercial medicines and the formulation 1 showed good stability, being possible to estimate the expiration time of 24 months.

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The development and validation of a reversed-phase liquid chromatographic (LC) method for the determination of sibutramine hydrochloride monohydrate in capsules is described. An isocratic LC analysis was performed on a reversed-phase RP-18 column (250 4.6 mm id, 5 m particle size). The mobile phase consisted of methanolwatertriethylamine (80 + 20 + 0.5, v/v/v), with pH adjusted to 5.65 with 85 phosphoric acid, and was pumped at a constant flow rate of 1.0 mL/min. Measurements were made at a wavelength of 223 nm. The calibration curve was linear over the range of 1540 g/mL [correlation coefficient (r2) = 0.9998]. The relative standard deviation (RSD) value for intraday precision was 0.84. The RSD value for interday precision was 0.90. Recoveries ranged from 99.64 to 100.66. No interferences from the excipients were observed. Because of its simplicity and accuracy, the method is suitable for routine quality control analysis of sibutramine in capsules.

This reports an analysis of the application of Project-Based Learning (PBL) methodology with a group of 17 students of the 4th grade of an elementary school at Taubaté town, São Paulo State, Brazil. The objective was to teach concepts related to noise pollution in order to educate kids committed to the environment. The project was developed with teams using eight stages applied between April and June of 2018. The social-emotional skills were observed at all stages, which contributed to the development of the concept of pollution. Although some students had shown difficulties to work in teams, they finished their activities and recognized their needs to improve collaboration. In addition, they also understood the dangers of noise pollution and the importance of changing habits in their daily lives.