Side effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with vivax malaria in Mâncio Lima, Acre, treated with chloroquine and primaquine. Patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these drugs after treatment was started. The most frequent symptoms before medication were headache, fever, chills, sweating, arthralgia, back pain, and weakness, which were present in between 40% and 76% of respondents. The treatment reduced the occurrence of these symptoms and reduced the lack of appetite, but gastrointestinal symptoms and choluria increased in frequency. There were no reports of pale stools before medication, but 12% reported the occurrence of this symptom after treatment started. Other symptoms such as blurred vision (54%), pruritus (22%), paresthesia (6%), insomnia (46%), and “stings” into the skin (22%) were reported after chloroquine was taken. The antimalarial drugs used to treat P. vivax malaria reduce much of the systemic and algic symptoms but cause mainly gastrointestinal side effects that may lead to lack of adherence to drug treatment. It is important to guide the patient for the appearance and the transience of such side effects in order to avoid abandoning treatment.

O ensino médico há alguns anos vem passando por uma transição do modelo clássico teórico para abordagens práticas e baseadas em problemas. Fundamentando-se em uma abordagem prática ambulatorial, criou-se um projeto de extensão para o ensino simultâneo a alunos de diferentes anos do curso médico com uma população ribeirinha, em que cada acadêmico utilizou suas habilidades adquiridas no curso para a criação de um serviço ambulatorial (acolhimento, pré-consulta, consulta médica, vacinação e dispensação de medicamentos), de forma a promover um serviço de saúde. Esta ação ocorreu em áreas remotas da Amazônia brasileira, mostrando que é possível unir extensão e ensino na formação de médicos mais conscientes das diferentes realidades socioeconômicas e culturais brasileiras.

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Background: Malaria remains a health problem in the Amazon and since 2005 the state of Acre has high incidence of malaria. Treatment with Coartem® for cases of falciparum malaria was introduced in Acre in August 2012. In Brazil, there is still no published study on the effectiveness of Coartem in endemic areas. Methods: This study was conducted in Mâncio Lima, Acre, in the western Brazilian Amazon region. All malaria cases notified in Mâncio Lima between August 01st, 2012 and October 31st, 2013 were revised. The therapeutic response to Coartem in Mâncio Lima, Acre, was evaluated. A recurrence of falciparum malaria was defined as a malaria case occurring in the same patient in a maximum interval of 40 days between the day treatments was started and the day the next diagnosis was made. Results: All malaria cases (7,171) notified between August 2012 and July 2013 were revised. About 23.72% (n = 1,701) were falciparum malaria. There were six cases of recurrent falciparum malaria that can be classified as treatment failure. All cases had low parasitemia. The minimum and maximum interval between the first and the recurrent malaria episode was 17 days and 33 days. Age range was 9 to 50 years. Two patients were from rural areas, while all others were from riverine areas. Conclusion: Possible failure to Coartem treatment was identified, however causes are not clear. Further studies are needed.

. 4 Professor pela Universidade Federal do Acre (UFAC), Rio Branco, Acre, Brasil. 5 Acadêmicos do Curso de Medicina, Universidade Federal do Acre (UFAC), Rio Branco, Acre, Brasil. RESUMOA plasticidade neuronal é expressão da capacidade adaptativa do sistema nervoso às mudanças ambientais, traduzindo-se lados das membranas celulares bem como da liberação de neurotransmissores nas fendas sinápticas. Portanto, mudanças nesses parâmetros do sistema motor podem alterar a atividade motora somática. Objetivo: determinar a ação de diferentes doses de Clonazepam combinado com exercício físico (natação) sobre a atividade motora em camundongos Swiss. Results and Discussion: The increase in motor activities is opposite to the normal habituation of animals. Conclusions: strengthens the motor activity, probably through neural plasticity mechanisms.