A set of (p-cymene)-ruthenium amino acid bioconjugates 1 and 2 is reported.The bioconjugates 2 show micromolar affinity for proteins.Increased potency and selectivity of 2 towards cancer cell lines is detected.The cytotoxicity of bioconjugates 2 is in correlation with their BSA binding constants.Cell stress response includes increase of cells in S phase of cell cycle, induction of autophagy and use of GSH as detoxification mechanism.
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