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SummaryCorrelation between chemical structure and Rf-values was studied in the case of aniline and its derivatives using high performance TLC and a U-chamber. The characteristic group constants referring to each substituent were determined by chromatographing derivatives with one substituent and aniline in toluene and dibutyl ether respectively. On the basis of these constants the RM and Rf values of derivatives with more substituents were calculated. Comparing the calculated and measured values good agreement was found.

HPTLC has proved to be an useful method for purity and stability control and for the quantitative determination of pharmaceutically important compounds. This work deals with two problems in this field.