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Background: Global interferon-␤ deficiency causes osteoporosis. Lack of interferon-␤ production by osteoclast precursors is considered to induce excess osteoclastogenesis. Results: Isolated osteocytes express higher amount of interferon-␤ mRNA than osteoclast precursors and inhibit osteoclastogenesis partially in interferon-␤-dependent manner. Conclusion: Osteocytes produce interferon-␤ as an inhibitor of osteoclastogenesis. Significance: Osteocytic interferon-␤ might be involved in the regulation of bone homeostasis.

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