District Ghizer is a rugged mountainous territory which experiences several landslides each year. There are 16 major landslide areas and 53 villages that are at high risk to hazards. Keeping in view the severity of natural hazards, the present study was designed to generate landslide susceptibility map based on twelve causative factors viz., slope, aspect, elevation, drainage network, Stream Power Index (SPI), Topographic Wetness Index (TWI), lithological units, fault lines, rainfall, road network, land cover and soil texture. Soil texture was determined by particle size analysis and data for other factors were acquired from freely available sources. Analytical Hierarchy Process (AHP) was employed to identify major landslide causative factors in the district Ghizer. Further, a temporal assessment from 1999 till 2015 was generated to assess the impact of land cover change on landslides. It indicated that the barren soil/ exposed rocks and glaciers have reduced while the vegetation and water classes have shown increment. The total area that lies in moderate to very high landslide susceptible zones was 74.38%, while slope is the main landslide causative factor in the district Ghizer. Validation of the susceptibility map showed 88.1% of the landslides in the study area had occurred in the moderate to very high susceptible zones.

Aging is associated with increased levels of coagulation factors and decrease in natural anticoagulant factors. This strongly supports that age-related hypercoagulable state occurs in elderly. This study aimed to measure the plasma levels of coagulation factors and anticoagulant levels in young and elderly to observe the effect of age on haemostatic system. Ninety healthy individuals, both men and women were divided into two groups on the basis of age. Group I included participants of less than 40 years of age, whereas, group II comprised of participants more than 60 years of age. Fibrinogen activity was assessed by using Clauss technique. Coagulation factor VII, and factor VIII activity by corresponding one stage assay based on prothrombin time and activated partial thromboplastin time. Antithrombin III was measured by the chromogenic method. Our results showed that significantly increased levels of fibrinogen (P = 0.001) were observed in the elderly population as compared to young. Higher fibrinogen levels in younger women than men and comparatively higher level than other races was observed in our local population. Increase in factor VII levels (P = 0.05) was also observed in the elderly group. This increase was statistically significant with age in women (P = 0.03). Factor VIII rose with age in both sexes (P = 0.001). Higher antithrombin activity was observed in the younger group whereas the older group demonstrated significantly lower antithrombin activity (P = 0.001). We conclude that considerable effects of age and sex are observed on coagulation factors and naturally occurring inhibitors.

List of abbreviations SSO-Sesame seed oil HDL-C-High-density lipoprotein Cholesterol TG-Triglycerides LDL-C-Low-density lipoprotein Cholesterol TC-Total cholesterol VLDL-C-Very low-density lipoprotein Cholesterol AHA-American heart association CVDs-Cardiovascular Diseases

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<p>Poly Cystic Ovary Syndrome is the hormonal imbalance that is by and large considered to affect more or less 10% of the female population. PCOs is more common in obese and overweight women, which further increases androgen secretion causing impaired metabolism and reproductive functions. Women with PC-OS are at increased risk of developing cardiovascular diseases, dyslipidemias, hypertension and type II diabetes Mellitus. Weight reduction is difficult to achieve in obese women with PCOS than normal individuals. So a comprehensive lifestyle intervention program including individualized diet with moderate energy restriction based on basic healthy eating principles, at least 30 minutes moderate physical activity 3-5 days a week and behavior modification approach is required. Hypocaloric diets along with modification of carbohydrates have found to be effective. Selection of foods among low glycemic load (GL) and high fiber foods and replacing fats with polyunsaturated fats may be a helpful strategy in PCOS patients.</p>