With the recent availability of ( -)-[3H]nicotine of high specific activity, binding studies were performed on rat brain membranes in the presence of a variety of nicotine analogues and cholinergic drugs. Both a higher affinity (& = 2 x lo-" M) and a lower affinity (2 x 10e9 M) site were observed; the stereoselectivity of both sites being similar. A good correlation was observed between Z&-values and psychotropic potency of a series of N'alkyl substituted nicotine analogues. Nicotine receptor Rat brain Nicotine analogue Cholinergic drugNicotine psychopharmacology

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