We are in an increasingly disruptive context, in an Era in which the world presents challenging and growing levels of uncertainty, unpredictability, and complexity. As a result, society is facing, at all levels and in all areas, more and more global challenges, challenging its stability and prosperity, whether at a technological, economic, social, environmental, or educational level. The new Era, Era 5.0, which places the human being at the center of innovation and technological transformation, can and must make its contribution to improving the quality of life, solving social problems, and human well-being, with the support of technology. Thus, this work intends, based on a systematic review of the literature, to analyze the challenges of Era 5.0 and its impacts on industry, society, and education as engines and promoters of the path to sustainable development. The results of this work show that the challenges for industry and education on the road to a “new” society are immense, in order to achieve a more humanistic society, centered on human beings, quality of life, and sustainability. We believe in contributing to the state of the art in Era 5.0 and providing an analytical reflection in the field of education and industry, on the path towards a society that places the human being at the center of innovation and technological transformation.