L ópez-P érez, ME, Romero-Arenas, S, Colomer-Poveda, D, Keller, M, and M árquez, G. Psychophysiological responses during a cycling test to exhaustion while wearing the elevation training mask. J Strength Cond Res 36(5): 1282-1289, 2022-The aim of this study was to investigate the psychophysiological effects of wearing the elevation training mask (ETM). Twelve men performed time-toexhaustion (TTE) tests at 75% of peak power output with and without wearing the ETM. Heart rate (HR), rating of perceived exertion (RPE), breathing discomfort (BD), and oxygen saturation (SpO 2 ) were measured during the TTE. Prefrontal cortex (PFC) and vastus lateralis oxygenated, deoxygenated, and total hemoglobin were monitored using near-infrared spectroscopy. At the end of each test, blood lactate values (La-) were collected, and subjects completed the Beck Anxiety Inventory (BAI). The mask caused a reduction in the TTE (237.7%; p , 0.001) and in the SpO 2 (22%; p , 0.001). Beck Anxiety Inventory scores were negatively correlated with the changes observed in the TTE (r 5 20.77; p , 0.01). La-, HR, and muscle oxygenation displayed similar results across conditions. In conjunction with an increased hemodynamic response in the PFC, subjects reported higher RPE and BD values in the ETM condition (p , 0.01). Finally, BAI scores were negatively correlated with the changes observed in the TTE (r 5 20.77; p , 0.01). This study suggests that wearing the ETM induces psychophysiological alterations affecting the exercise tolerance and limiting the performance.