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Letters lo the Editor tbe dermis. dilated blood vessels in the upper dermis with swollen endotbelial cells, mixed infiammatory infiltrate under tbe erosion and round-cellular perivascular infiltrate in tbe peripbery.Myelogram yielded hypocellular material with only solitary representatives of the wbite and red blood lines.Chest X-rays revealed bronchopneumonia in the lower field of the left lung. Serial hemocultures grew Enterococcu.s faeciuni.Therapy was initiated witb Erythran (600 mg four times daily), Rocefin {LO g, bid) and Metbylprednisolone at an initial dose of 100 mg with gradual tapering. Several infusions of erythrocytes and electrolyte solutions were performed. Tbe cutaneous lesions improved slowly, witb complete clearance in 40 days.The haematological disorders that are most often associated witb pyoderma gangrenosum are acute and chronic myeloid leukaemia, polycytemia vera. monoclonal gammapathy. paroxismal nocturnal haemoglobinuria, non-Hodgkin lymphomas, erythroid hypoplasia, myelodysplasia, myelofibrosis and myeloma [5].Haematological disorders are rare but well known complications of methotrexate treatment. Leukopenia is more common than thrombocytopenia. Agranulocytosis, here described, in association witb P.G. is an extremely rare complication [6].