Yacon (Smallanthus sonchifolius) is a tuber with a high content of active compounds that offer health benefits, so its productive chain seeks new alternatives to generate yacon products with added value; however, it tends to be a perishable product due to its high aw, chemical composition, and enzymatic activity. The influence of both composition and homogenization in the colloidal stability of yacon suspensions was evaluated for later use in spray drying. Response surface methodology and a central composite design were used, considering three independent variables: homogenization time (TH) (4-6 min), xanthan gum (XG) (0.1-0.2%), and acidity (0.1-0.3%); and the following dependent variables: zeta potential (ζ), color (CIELab), viscosity (μ), stability index by spectral absorption (R), and particle size (D10, D50, and D90). The values of the independent variables that best fit the experimental optimization criteria were: XG=0.16%, acid=0.3%, and TH=4.8 min. The values of the experimental dependent variables and the variables predicted by the quadratic model were ζ=-33.8±4.0 and -37.6 mV, µ=1143.0±93.4 and 1000 cP, R=0.45±0.1 and 0.48, D10=127.8±8.2 and 138.1 µm, D50=251.2±16.3 and 267.7 µm, D90=424.3±28.7 mm and 463.9 µm, L*=41.7±1.4 and 41.8, a*=0.02±0.85 and 1.6, and b*=15.0±1.3 and 14.8, respectively. The colloidal suspension showed adequate physicochemical stability, favored mainly by repulsive forces, homogenization, and rheology of the continuous phase; reaching a content of total solids of 12.5%.
