Summary
We report a case of a previously healthy 24-year-old man with a 3-month history of gastrointestinal symptoms during exercise and also few minutes after the ingestion of cow's milk (CMBodybuilding protein supplements and cow's milk allergy in adult
Previous presentationThe data reported in this study was presented by Maria João Sousa (co-authors: Ferreira AR, Moreira Silva JP) at the EAACI Congress 2015 in Barcelona (Spain) 6-10 June 2015, as a poster entitled "Adult-onset cow's milk allergy and Bodybuilding: is there a connection?". It was awarded the Poster Prize (Thematic Poster Session 54) and was published in the abstract form in Allergy 2015; 70(Suppl. S101):611; at the 36a Reunião Anual da Sociedade Portuguesa de Alergologia e Imunologia Clínica in Coimbra (Portugal) 9-11 October 2015, as a poster entitled "Alergia às proteínas do leite de vaca: uma apresentação incomum". It was awarded the 1 st Poster Prize (Poster Session IV) and was published in the abstract form in Rev Port Imunoalergologia 2015; 23(Suppl. 1):64.
Non-specific lipid transfer proteins (LTP) are panallergens present in plant-foods, being the most relevant allergens of Rosacea family fruits in the Mediterranean area (1,2). These ubiquitous proteins are highly conserved and widely distributed in the plant kingdom, sharing a moderate-to-high homologous molecular structure, which put the patients allergic to LTP at risk of developing allergic reactions after the ingestion of an array of botanically unrelated foods, including fruits, tree nuts, seeds, vegetables and cereals (1,3-7).Despite the fact that milk and egg proteins are the main causes of food allergy in childhood, fruits and vegetables have been recognized as emergent allergens in pediatrics (8).Since LTP may cause severe systemic reactions it is essential to better understand this allergy in childhood.Even though multiple studies on LTP have been published in the last years, so far, not much is known about LTP allergy in children, especially regarding daily practice, since only a few case series focused on pediatric ages have been published (9-13). A recent study has shown that fresh fruits are the 5th cause of anaphylaxis in children, with tree nuts being the 2 nd , both potentially caused by LTP in this region (14).Our aim was to characterize a series of children with allergy to LTP, in order to better understand its characteristics.
M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n
MethodsWe performed a retrospective analysis of medical records from patients under 18 years-old with confirmed LTP allergy (2013)(2014)(2015)(2016)(2017)(2018)(2019).Diagnosis was established based on a convincing history of immediate allergic reactions to plant-foods (i.e. repeated symptoms to LTP containing foods on several occasions) supported by positive skin prick tests (SPT) (defined as the mean diameter of the wheal ≥ 3 mm than negative control ( 15)) to LTP extract (Roxall, Bilbao, Spain) and positive specific IgE (sIgE) to LTP allergens (Pru p 3, Cor a 8 and/or Jug r 3) determined by ImmunoCAP (ThermoFisher Scientific, Uppsala, Sweden; cut-off: ≥0.35 kUA/L) and/or ImmunoCAP TM ISAC microarray
A análise do suporte destas pinturas surge no seguimento da investigação acerca das técnicas e materiais presentes na obra do pintor e desenvolveu -se através da observação à vista desarmada (usando diferentes condições de iluminação), da fotografia de radiação visível e da radiografia. Pontualmente foi utilizado o microscópio ótico portátil. Este estudo permitiu conhecer as técnicas de execução dos painéis e identificar intervenções de conservação e restauro de que foram alvo ao longo da sua história.
Palavras -chavePainel; castanho; técnica; conservação; Diogo Teixeira. microscope. This study supports the identification of the technical execution of the wooden panels and also the restorations that were made throughout its history.
Material and
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.