We report a case of spontaneous uterine rupture caused by placenta percreta at 18 weeks' gestation after in vitro fertilization. Spontaneous uterine rupture is an extremely infrequent obstetric complication that may compromise the lives of the fetus and the mother. We describe the case of a pregnant woman at 18 weeks' gestation who presented with sudden abdominal pain and severe hemoperitoneum. We noticed a uterine rupture and carried out an urgent obstetric hysterectomy. The patient died due to hypovolemic shock and severe generalized coagulopathy. The pregnancy had been obtained via in vitro fertilization techniques. The patient did not have any risk factor or antecedent. The anatomopathological study showed a fundus uterine rupture caused by placenta percreta.

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