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Ethics approval statementAll human and animal studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Intracellular calcium mediates the bidirectional coupling between excitation and contraction (ECC) in cardiac myocytes, whereby calcium affects electrophysiology and vice versa. Abnormalities in ECC can precipitate

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